If you are developing HTML5 mobiles apps you've probably ran into this error where the ajax requests couldn't go through. It seems the Cross Domain Proxy is set to Remote by default. You can change it in the Settings > Cross Domain Proxy > to Local, Disabled or Remote (default).
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How do you keep it set to "disabled" by default? It keeps resetting itself back to local often.
Maybe it's not saving the option or something.